despite和although区别：中文意思不同、词性用法不同、侧重点不同。despite是介词，意为即使、尽管等，后面只能加名词性短语或代词；although是连词，意为虽然、不过、然而等，通常用在句首或句中。
一、中文意思不同
1、despite作为介词，有即使;尽管;尽管(自己)不愿意等含义。
例句：She was good at physics despite the fact that she found it boring.
尽管她认为物理枯燥无味，她却学得很好。
He had to laugh despite himself.
他不想笑，但还是忍不住笑了出来。
2、although作为连词，有虽然;尽管;即使;不过;然而等含义。
例句：Although the sun was shining it wasn't very warm.
尽管太阳高照，却不很暖和。
I felt he was wrong, although I didn't say so at the time.
我觉得他错了，不过我当时没有说出来。
二、用法不同
1、despite：固定搭配有in despite of、despite of，表示不管、尽管，但是使用不普遍，从语气上看，despite比in spite of要轻。
2、although：常用于引导陈述语气的让步状语从句，且引导的句子常指事实，而不指设想。
三、侧重点不同
1、despite：后面只能加名词性短语或代词。
2、although：通常用在句首或句中。
